Tricarboxylic acids and derivatives
Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Inhibits SDMA and cell proliferation in MTAP-del cells
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
- Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
- Favorable ADME profile with high bioavailability and moderate to high clearance
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | C15H22O8S | 10MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker with a tosyl cap and a three-unit polyethylene glycol spacer terminating in a carboxylic acid. It is designed for use in the synthesis of PROTACs and other bifunctional molecules where a short, flexible, polar spacer and a carboxyl functional handle are required.
- Tosyl-capped PEG3 spacer ending in a carboxylic acid for conjugation.
- Provides a short, flexible, hydrophilic linker suitable for cellular applications.
- Terminal carboxyl group enables amide or ester coupling chemistries.
- Compatible with solid-phase and solution-phase synthetic workflows.
- Supplied in research-scale quantities for medicinal chemistry and PROTAC development.
- Molecular formula C15H22O8S, molecular weight ≈362.40 g/mol.
Medchemexpress LLC Gefapixant citrate | 2310299-91-1 | 99.2% | 545.52 g/mol | C20H27N5O11S | 5 MG
Gefapixant citrate is the citrate salt of gefapixant, an orally active P2X3 receptor antagonist used in research on chronic cough and pain-related indications. Supplied as a research-grade solid with high purity, it is suitable for in vitro and in vivo studies and is accompanied by technical documentation for analytical use.
- Potent P2X3 receptor antagonist with low-nanomolar activity.
- High purity suitable for research applications.
- Available in small solid quantities for dose-ranging studies.
- Includes datasheet, certificate of analysis, and safety data sheet documentation.
- Soluble stock solutions offered for convenient preparation.
Medchemexpress LLC ARL67156 trisodium hydrate | MFCD12910436 | 99.9% | 834.61 g/mol | C15H23Br2N5Na3O13P3 | 1 MG
ARL67156 trisodium hydrate is the trisodium salt hydrate form of ARL67156 (FPL 67156), a small-molecule inhibitor of ecto-ATPases used in research to study extracellular ATP signaling and disease models such as calcific aortic valve disease and asthma.
- Inhibits ecto-ATPase enzymes, including NTPDase1 (CD39), NTPDase3, and NPP1.
- Reported Ki values: 11 μM, 18 μM, and 12 μM for NTPDase1, NTPDase3, and NPP1, respectively.
- Purity 99.94% as reported on the product page.
- Supplied as a trisodium hydrate salt.
- Available in small research quantities (for example, 1 mg and 5 mg sizes).
Medchemexpress LLC Fmoc-NH-PEG1-CH2COOH | 260367-12-2 | 99.5% | 341.36 g/mol | C19H19NO5 | 1 G
Fmoc-NH-PEG1-CH2COOH is an Fmoc-protected PEG-based linker with a terminal carboxylic acid, designed for installation of linkers in medicinal chemistry workflows such as ADC and PROTAC synthesis.
- Used in antibody-drug conjugate linker synthesis.
- Used in proteolysis-targeting chimera (PROTAC) synthesis.
- Contains an Fmoc-protected amine and a terminal carboxylic acid for conjugation.
- White to off-white solid with good purity for research applications.
- Available in multiple sizes, including 1 g, for flexible laboratory use.
Chem-Impex International, Inc. Sodium citrate dihydrate | 6132-04-3 | MFCD00150031 | 2.5KG
Sodium citrate dihydrate, 6132-04-3, MFCD00150031, 2.5KG
Medchemexpress LLC 5,8,11,14,17,20-hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | 99.4% | 561.62 | C29H39NO10 | 250 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected polyethylene glycol (PEG6) linker with a terminal carboxylic acid, supplied for research use as a cleavable linker for antibody-drug conjugates and as a PEG-based PROTAC linker in targeted protein degradation research.
- Fmoc-protected amine with terminal carboxylic acid functionality.
- Suitable for ADC and PROTAC linker synthesis.
- Reported purity 99.4% and molecular weight 561.62.
- Molecular formula C29H39NO10.
- Available in small-scale pack sizes including 250 MG.
Medchemexpress LLC Amino-PEG3-CH2COOH | 134978-99-7 | 99.9% | C8H17NO5 | 100 MG
Amino-PEG3-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Diphosphoric acid, mono[(2E)-4-hydroxy-3-methyl-2-butenyl] ester, triammonium salt | 443892-56-6 | 90.0% | C5H21N3O8P2 | 500 UG
HDMAPP triammonium is a potent phosphoantigen in the ammonium and pyrophosphate form of (E)-HDMAPP. It is an activator of γδ T cells and can induce T cell stimulation in vitro with an EC₅₀ of 0.39 nM for TNF-α release.
- Potent phosphoantigen
- Activates γδ T cells
- Induces T cell stimulation in vitro
- Increases TNF-α release in human Vγ9Vδ2 T cells
- Significantly increases γδ cells in cynomolgus monkey model
- White to off-white solid appearance
Medchemexpress LLC Mosapride citrate | 112885-42-4 | 99.96% | 5 MG
Mosapride citrate is an orally active gastroenterokinetic compound, acting as a 5HT4 agonist and a CYP inducer. It demonstrates a concentration-dependent inhibitory effect on Kv4.3 with an IC50 value of 15.2 μM. This compound is suitable for use in the study of gastrointestinal diseases.
- Acts as a 5HT4 agonist
- Functions as a CYP inducer
- Exhibits concentration-dependent inhibitory effect on Kv4.3 with an IC50 of 15.2 μM
- Promotes gastric emptying
- Relieves NSAID-induced ulcers by activating the 5-HT4 receptor
Medchemexpress LLC Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | 99.4% | 5 G
Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This compound leverages the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Cleavable ADC linker
- PEG-based PROTAC linker
- Utilized in antibody-drug conjugate (ADC) synthesis
- Used in PROTAC synthesis
- Leverages intracellular ubiquitin-proteasome system
Medchemexpress LLC Mosapride citrate | 112885-42-4 | 99.9% | 1 ML
Mosapride citrate is an orally active gastroenterokinetic compound. It acts as a 5HT4 agonist and a CYP inducer. It exhibits a concentration-dependent inhibitory effect on Kv4.3, with an IC50 value of 15.2 μM. Mosapride citrate is used in the study of gastrointestinal diseases.
- Orally active gastroenterokinetic compound
- 5HT4 agonist
- CYP inducer
- Inhibitory effect on Kv4.3
- Useful for studying gastrointestinal diseases
Selleck Chemical LLC Citric acid trilithium salt tetrahydrate S4519-100mg
Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material It is commonly used in HPLC gradient elution for quantification of amino acids
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 250 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
- Suitable for cancer targeted therapy research